ARG45167
Anti-C9orf72 antibody
Anti-C9orf72 antibody for Flow cytometry,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes C9orf7 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | C9orf7 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to N-terminal region of human C9orf7. |
| 偶联标记 | Un-conjugated |
| 別名 | C9ORF72; C9orf72-SMCR8 complex subunit; Guanine nucleotide exchange C9orf72; C9orf72 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 65 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | C9ORF72 |
| 全名 | C9orf72-SMCR8 complex subunit |
| 背景介绍 | The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2016] |
| 生物功能 | Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophag. [UniProt] |
| 细胞定位 | Secreted; Lysosome; Endosome; Nucleus; Cytoplasm, P-body; Cytoplasm; Cell projection, axon 1; Cell projection, growth cone; Perikaryon; dendrite; Nucleus membrane; Peripheral membrane protein. [UniProt] |
| 预测分子量 | 54 kDa |
检测图片 (4) Click the Picture to Zoom In
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ARG45167 Anti-C9orf72 antibody FACS image
Flow Cytometry: U20S stained with ARG45167 Anti-C9orf72 antibody at 1 µg/10^6 cells dilution.
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ARG45167 Anti-C9orf72 antibody WB image
Western blot: Hela, A431, and A549 stained with ARG45167 Anti-C9orf72 antibody at 0.5 μg/ml dilution.
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ARG45167 Anti-C9orf72 antibody WB image
Western blot: Rat brain, rat liver, and C6 stained with ARG45167 Anti-C9orf72 antibody at 0.5 μg/ml dilution.
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ARG45167 Anti-C9orf72 antibody WB image
Western blot: Mouse liver and HEPA1-6 stained with ARG45167 Anti-C9orf72 antibody at 0.5 μg/ml dilution.
