ARG70529
Human CD124 / IL4 Receptor recombinant protein (His-tagged)
Human CD124 / IL4 Receptor recombinant protein (His-tagged) for SDS-PAGE
概述
| 产品描述 | HEK293 expressed, His-tagged Human CD124 / IL4 Receptor recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | CD124 / IL4 Receptor |
| A.A. 序列 | Met26 - His232 |
| 表达系统 | HEK293 |
| 別名 | IL4R; Interleukin 4 Receptor; CD124; Interleukin-4 Receptor Subunit Alpha; IL-4 Receptor Subunit Alpha; Interleukin 13 Receptor; IL-4RA; IL4RA; Interleukin-4 Receptor Alpha Chain; IL-4R Subunit Alpha; CD124 Antigen; IL-4R-Alpha |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/ml and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | IL4R |
|---|---|
| 全名 | Interleukin 4 Receptor |
| 背景介绍 | This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012] |
| 生物功能 | Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. [Uniprot] |
