ARG83333
Human CD204 / MSR1 ELISA Kit
Human CD204 / MSR1 ELISA 试剂盒 for ELISA and Human
概述
| 产品描述 | ARG83333 Human CD204 / MSR1 ELISA Kit is a high sensitive Enzyme Immunoassay kit for the quantification of Human CD204 / MSR1 in Serum, Plasma, Cell culture supernatants. |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 特异性 | There is no detectable cross-reactivity with other relevant proteins. |
| 靶点名称 | CD204 / MSR1 |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm |
| 灵敏度 | 45 pg/ml |
| 检测范围 | 93.7 - 6000 pg/ml |
| 样品类型 | Serum, Plasma, Cell culture supernatants |
| 精确 | CV: less than10% |
| 別名 | MSR1; Macrophage Scavenger Receptor 1; SCARA1; SR-AIII; SR-AII; CD204; SR-AI; SR-A; Macrophage Scavenger Receptor Types I And II; Macrophage Acetylated LDL Receptor I And II; Scavenger Receptor Class A Member 1; Macrophage Scavenger Receptor Type III; CD204 Antigen; PhSR1; PhSR2; SRA |
应用说明
| 检测时间 | 4.5 hours |
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属性
| 形式 | 96 well |
|---|---|
| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P21757 Human Macrophage scavenger receptor types I and II |
|---|---|
| 基因名称 | MSR1 |
| 全名 | Macrophage Scavenger Receptor 1 |
| 背景介绍 | This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. |
| 生物功能 | Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). |
| 细胞定位 | LDL, Membrane |
| 翻译后修饰 | Disulfide bond, Glycoprotein, Phosphoprotein |
检测图片 (1) Click the Picture to Zoom In
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ARG83333 Human CD204 / MSR1 ELISA Kit standard curve image
ARG83333 Human CD204 / MSR1 ELISA Kit results of a typical standard run with optical density reading at 450 nm.
| Title | Download Link |
|---|---|
| ARG83333 Human CD204 / MSR1 ELISA Kit User manual |
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