ARG70371
Human CD68 recombinant protein (Fc-tagged, C-ter)
Human CD68 recombinant protein (Fc-tagged, C-ter) for SDS-PAGE and Human
Immune System antibody; Activated Macrophage/Microglia Study antibody; Neuroinflammation Study antibody; Active macroglial Marker antibody; M1/M2/TAM Marker antibody; Macrophage Marker antibody; M1 macrophage Marker antibody; Inflammatory Cell Marker antibody
概述
| 产品描述 | HEK293 expressed, Fc (rabbit)-tagged (C-ter) Human CD68 recombinant protein. |
|---|---|
| 反应物种 | Hu |
| 应用 | SDS-PAGE |
| 靶点名称 | CD68 |
| 物种 | Human |
| A.A. 序列 | Asn22 - Ser319 of Human CD68 (NP_001242.2) with a rabbit Fc tag at the C - terminus. |
| 表达系统 | HEK293 |
| 別名 | Macrosialin; CD antigen CD68; LAMP4; Gp110; GP110; SCARD1 |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | 0.22 µm filter sterilized. Endotoxin level is <0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 97% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | Reconstitute to a concentration of 0.1 - 0.5 mg/ml in sterile distilled water. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | CD68 |
|---|---|
| 全名 | CD68 molecule |
| 背景介绍 | CD68 is a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008] |
| 生物功能 | CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. [UniProt] |
| 产品亮点 | Related Antibody Duos and Panels: ARG30325 Inflammatory Cell Antibody Panel Related products: CD68 antibodies; CD68 Duos / Panels; Anti-Rabbit IgG secondary antibodies; Related news: Cancer Pathology Markers (SQ clones) New antibody panels and duos for Tumor immune microenvironment Tumor-Infiltrating Lymphocytes (TILs) Exploring Antiviral Immune Response Anti-SerpinB9 therapy, a new strategy for cancer therapy RIP1 activation and pathogenesis of NASH |
| 研究领域 | Immune System antibody; Activated Macrophage/Microglia Study antibody; Neuroinflammation Study antibody; Active macroglial Marker antibody; M1/M2/TAM Marker antibody; Macrophage Marker antibody; M1 macrophage Marker antibody; Inflammatory Cell Marker antibody |
| 翻译后修饰 | N- and O-glycosylated. [UniProt] |
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ARG70371 Human CD68 recombinant protein (Fc-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70371 Human CD68 recombinant protein (Fc-tagged, C-ter).
