ARG70391
Human CHI3L1 recombinant protein (His-tagged, C-ter)
Human CHI3L1 recombinant protein (His-tagged, C-ter) for SDS-PAGE
概述
| 产品描述 | E. coli expressed, His-tagged (C-ter) Human CHI3L1 recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | CHI3L1 |
| 物种 | Human |
| A.A. 序列 | Tyr22 - Thr383 |
| 表达系统 | E. coli |
| Protein Full name | Chitinase-3-like protein 1 |
| 別名 | CHI3L1; Chitinase 3 Like 1; YKL40 YK-40; GP39; Chitinase 3-Like 1 (Cartilage Glycoprotein-39); Chitinase-3-Like Protein 1; Cartilage Glycoprotein 39; 39 KDa Synovial Protein; HCGP-39; CGP-39; YKL-40; GP-39; Cartilage Glycoprotein-39; HC-Gp39; HCGP-3P; YYL-40; ASRT7 |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 98% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | CHI3L1 |
|---|---|
| 全名 | Chitinase 3 Like 1 |
| 背景介绍 | Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. |
| 生物功能 | Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. |
| 细胞定位 | Cytoplasm, Endoplasmic reticulum, Secreted |
| 翻译后修饰 | Disulfide bond, Glycoprotein |
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ARG70391 Human CHI3L1 recombinant protein (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70391 Human CHI3L1 recombinant protein (His-tagged, C-ter)
