ARG70367
Human Eotaxin 3 recombinant protein (Active) (Tag free)
Human Eotaxin 3 recombinant protein (Active) (Tag free) for Functional study,SDS-PAGE and Human
概述
| 产品描述 | E. coli expressed Active Human Eotaxin 3 recombinant protein |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms |
| 应用 | FuncSt, SDS-PAGE |
| 靶点名称 | Eotaxin 3 |
| 物种 | Human |
| A.A. 序列 | TRGSD ISKTC CFQYS HKPLP WTWVR SYEFT SNSCS QRAVI FTTKR GKKVC THPRK KWVQK YISLL KTPKQ L |
| 表达系统 | E. coli |
| 生物活性 | Active |
| 活性说明 | Determined by its ability to chemoattract human CCR3/HEK293 cells. The maximum activity was achieved at 2μg/ml. |
| 別名 | CCL26; C-C motif chemokine ligand 26; IMAC; TSC-1; MIP-4a; SCYA26; MIP-4alpha; CC chemokine IMAC; Eotaxin-3; Macrophage inflammatory protein 4-alpha (MIP-4-alpha); Small-inducible cytokine A26; SCYA26; Thymic stroma chemokine-1 |
应用说明
| 实际分子量 | 8.4 kDa |
|---|
属性
| 形式 | Powder |
|---|---|
| 纯化 | Affinity purified. |
| 纯度 | ≥ 98% by SDS-PAGE gel and HPLC analyses. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | CCL26 |
|---|---|
| 全名 | C-C motif chemokine ligand 26 |
| 背景介绍 | This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. This protein also has antimicrobial activity, displaying an antibacterial effect on S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2020] |
| 生物功能 | Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca2+ mobilization in eosinophils. Also acts as a ligand for CX3C chemokine receptor CX3CR1, inducing cell chemotaxis [provide by uniprot] |
| 细胞定位 | Secreted |
| 预测分子量 | 10.6 kDa (full-length). 8.4 kDa (mature) |
| 翻译后修饰 | Disulfide bond |
