ARG70412
Human FGF8 (isoform B) recombinant protein (Active) (His-tagged, C-ter)
Human FGF8 (isoform B) recombinant protein (Active) (His-tagged, C-ter) for SDS-PAGE
概述
| 产品描述 | E. coli expressed, His-tagged (C-ter) Active Human FGF8 (isoform B) recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | FGF8 (isoform B) |
| 物种 | Human |
| A.A. 序列 | Gln52 - Arg223 |
| 表达系统 | E. coli |
| Protein Full name | Fibroblast growth factor 8 |
| 生物活性 | Active |
| 活性说明 | Determined by its ability to induce 3T3 cells proliferation. The ED50 for this effect is 1.4-3.8 ng/mL. The specific activity of recombinant human FGF-8b is > 2 x 10^5 IU/mg. |
| 別名 | FGF8; Fibroblast Growth Factor 8; AIGF; Androgen-Induced Growth Factor; Fibroblast Growth Factor 8 (Androgen-Induced); Heparin-Binding Growth Factor 8; HBGF-8; FGF-8; KAL6; HH6 |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 8.0) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | FGF8 |
|---|---|
| 全名 | Fibroblast Growth Factor 8 |
| 背景介绍 | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. |
| 生物功能 | Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. |
| 细胞定位 | Secreted |
| 翻译后修饰 | Glycoprotein |
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ARG70412 Human FGF8 (isoform B) recombinant protein (Active) (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70412 Human FGF8 (isoform B) recombinant protein (Active) (His-tagged, C-ter).
