概述

产品描述	ARG80503 Human IL1 beta ELISA Kit is an Enzyme immunoassay kit for in vitro quantitative measurement of human IL1 beta in serum and plasma (EDTA).
反应物种	Hu
应用	ELISA
靶点名称	IL1 beta
偶联标记	HRP
灵敏度	0.35 pg/ml
样品类型	Serum and plasma (EDTA).
标准范围	24 - 1166 pg/ml
样本量	200 µl
別名	Interleukin-1 beta; IL1-BETA; IL-1; IL-1 beta; Catabolin; IL1F2

应用说明

检测时间	2 h, 15 min (RT/shaker)

属性

形式	96 well
存放说明	Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 3553 Human IL1B Swiss-port # P01584 Human Interleukin-1 beta
基因名称	IL1B
全名	interleukin 1, beta
背景介绍	IL1 beta protein is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
生物功能	IL1 beta is a potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). [UniProt]
产品亮点	Related products: IL1 beta antibodies; IL1 beta ELISA Kits; IL1 beta Duos / Panels; IL1 beta recombinant proteins; Related news: HMGB1 in inflammation Inflammatory Cytokines Exploring Antiviral Immune Response RIP1 activation and pathogenesis of NASH New ELISA data calculation tool: Simplify the ELISA analysis by GainData
研究领域	Cell Biology and Cellular Response kit; Immune System kit; Metabolism kit
翻译后修饰	Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated.

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