ARG82947
Human IL17A / IL17F Heterodimer ELISA Kit
Human IL17A / IL17F Heterodimer ELISA 试剂盒 for ELISA and Human
概述
| 产品描述 | ARG82947 Human IL17A / IL17F Heterodimer ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human IL17A / IL17F Heterodimer in serum, plasma and cell culture supernatants. |
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| 反应物种 | Hu |
| 应用 | ELISA |
| 靶点名称 | IL17A / IL17F Heterodimer |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 23.44 pg/ml |
| 样品类型 | Serum, plasma and cell culture supernatants. |
| 标准范围 | 46.88 - 3000 pg/ml |
| 样本量 | 100 μl |
| 精确 | Intra-Assay CV: less than 10% Inter-Assay CV: less than 10% |
| 別名 | IL17A: IL-17A; Interleukin-17A; IL-17; CTLA8; IL17; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8 IL17F: Interleukin-17F; IL-17F; CANDF6; ML-1; ML1; Cytokine ML-1 |
应用说明
| 检测时间 | ~ 3.5 hours |
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属性
| 形式 | 96 well |
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| 存放说明 | Store the kit at 4°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | IL17A; IL17F |
|---|---|
| 全名 | interleukin 17A / interleukin 17F Heterodimer |
| 背景介绍 | IL17A: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008] IL17F: The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008] |
| 生物功能 | IL17A: Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080). [UniProt] IL17F: Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity). [UniProt] |
| 细胞定位 | IL17A and IL17F: Secreted. [UniProt] |
| 产品亮点 | Related products: IL17 antibodies; IL17 ELISA Kits; IL17 recombinant proteins; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| 翻译后修饰 | IL17A: Found both in glycosylated and nonglycosylated forms. [UniProt] |
| Title | Download Link |
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| ARG82947 Human IL17A / IL17F Heterodimer ELISA Kit User manual |
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