ARG83247
Human Langerin / CD207 ELISA Kit
Human Langerin / CD207 ELISA 试剂盒 for ELISA and Human
概述
| 产品描述 | ARG83247 Human Langerin / CD207 ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human Langerin / CD207 in Serum, Plasma and Cell culture supernatants. |
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| 反应物种 | Hu |
| 应用 | ELISA |
| 特异性 | There is no detectable cross-reactivity with other relevant proteins. |
| 靶点名称 | Langerin / CD207 |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 13 pg/ml |
| 检测范围 | 156 pg/ml - 10,000 pg/ml |
| 样品类型 | Serum, Plasma and Cell culture supernatants |
| 精确 | Intra-Assay CV: 5.8% Inter-Assay CV: 7.2% |
| 別名 | CD207; CD207 Molecule; CLEC4K; C-Type Lectin Domain Family 4 Member K Langerin; Langerhans Cell Specific C-Type Lectin; CD207 Molecule, Langerin; CD207 Antigen, Langerin; C-Type Lectin Domain Family 4, Member K; CD207 Antigen |
应用说明
| 检测时间 | ~ 5 hours |
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属性
| 形式 | 96 well |
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| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9UJ71 Human C-type lectin domain family 4 member K |
|---|---|
| 基因名称 | CD207 |
| 全名 | CD207 Molecule |
| 背景介绍 | The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. |
| 生物功能 | Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. |
| 细胞定位 | Membrane |
| 翻译后修饰 | Disulfide bond, Glycoprotein |
检测图片 (1) Click the Picture to Zoom In
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ARG83247 Human Langerin / CD207 ELISA Kit standard curve image
ARG83247 Human Langerin / CD207 ELISA Kit results of a typical standard run with optical density reading at 450 nm.
| Title | Download Link |
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| ARG83247 Human Langerin / CD207 ELISA Kit User manual |
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