ARG83019
Human / Mouse BMP10 ELISA Kit
Human / Mouse BMP10 ELISA 试剂盒 for ELISA and Human,Mouse
概述
| 产品描述 | ARG83019 Human / Mouse BMP10 ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human / Mouse BMP10 in serum, plasma (heparin), ascites, urine and cell culture supernatants. |
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| 反应物种 | Hu, Ms |
| 应用 | ELISA |
| 特异性 | Not cross-reacts with: Human BMP5, BMP6, BMP9, BMPR1A. Mouse BMP5, BMP6, BMP9, BMPR1A. Rat BMP5, BMP6, BMP9, BMPR1A. |
| 靶点名称 | BMP10 |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| Protein Full name | Bone morphogenetic protein 10 |
| 灵敏度 | 7.8 pg/ml |
| 样品类型 | Serum, plasma (heparin), ascites, urine and cell culture supernatants. |
| 标准范围 | 15.6 - 1000 pg/ml |
| 样本量 | 100 µl |
| 精确 | Intra-Assay CV: less than 10% Inter-Assay CV: less than 10% |
| 別名 | BMP10, Bone Morphogenetic Protein 10, BMP 10 |
应用说明
| 检测时间 | ~ 4 hours |
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属性
| 形式 | 96 well |
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| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | BMP10 |
| 全名 | Bone Morphogenetic Protein 10 |
| 背景介绍 | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. [provided by RefSeq, Aug 2016] |
| 生物功能 | Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. [Uniprot] |
| 细胞定位 | Secreted. [UniProt] |
| 产品亮点 | Related products: BMP antibodies; BMP ELISA Kits; BMP recombinant proteins; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| 翻译后修饰 | Cleavage on pair of basic residues, Disulfide bond, Glycoprotein. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG83019 Human/Mouse BMP10 ELISA Kit standard curve image
ARG83019 Human/Mouse BMP10 ELISA Kit results of standard run with optical density reading at 450 nm
| Title | Download Link |
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| ARG83019 Human/Mouse BMP10 ELISA Kit User manual |
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