ARG70084
Human TNFSF13 / APRIL recombinant protein (Active) (His-tagged, C-ter)
Human TNFSF13 / APRIL recombinant protein (Active) (His-tagged, C-ter) for SDS-PAGE
概述
| 产品描述 | E. coli expressed, His-tagged (C-ter) Active Human TNFSF13 / APRIL recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | TNFSF13 / APRIL |
| 物种 | Human |
| A.A. 序列 | Ala1 - Leu146 |
| 表达系统 | E. coli |
| 生物活性 | Active |
| 活性说明 | Determinedd by its ability to induce cell death in Jurkat cells. The ED50 for this effect is 2.6-4.0 μg/mL. |
| 別名 | TALL2; ZTNF2; TRDL-1; TNF- and APOL-related leukocyte expressed ligand 2; CD256; APRIL; A proliferation-inducing ligand; TNF-related death ligand 1; UNQ383/PRO715; CD antigen CD256; Tumor necrosis factor ligand superfamily member 13; TALL-2 |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 98% (by SDS-PAGE) |
| 缓冲液 | PBS containing 0.1% sarkosyl (pH 8.0) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | TNFSF13 |
|---|---|
| 全名 | tumor necrosis factor (ligand) superfamily, member 13 |
| 背景介绍 | The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010] |
| 生物功能 | Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 翻译后修饰 | The precursor is cleaved by furin. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG70084 Human TNFSF13 / APRIL recombinant protein (Active) (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70084 Human TNFSF13 / APRIL recombinant protein (Active) (His-tagged, C-ter).
