ARG70167
Mouse IL17 / IL17A recombinant protein (Active) (His-tagged, C-ter)
Mouse IL17 / IL17A recombinant protein (Active) (His-tagged, C-ter) for SDS-PAGE
概述
| 产品描述 | E. coli expressed, His-tagged (C-ter) Active Mouse IL17 / IL17A recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | IL17 / IL17A |
| 物种 | Mouse |
| A.A. 序列 | Ala26 - Ala158 |
| 表达系统 | E. coli |
| 生物活性 | Active |
| 活性说明 | Determined by its ability to induce IL-6 secretion in 3T3 cells. The ED50 for this effect is < 1 ng/mL. The specific activity of recombinant mouse IL-17A is > 1 x 10^6 IU/mg. |
| 別名 | IL-17A; Interleukin-17A; IL-17; CTLA8; IL17; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8 |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 98% (by SDS-PAGE) |
| 缓冲液 | 20 mM sodium citrate and 0.2 M NaCl (pH 4.5) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | IL17A |
|---|---|
| 全名 | interleukin 17A |
| 背景介绍 | The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008] |
| 生物功能 | Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 产品亮点 | Related products: IL17 antibodies; IL17 ELISA Kits; IL17 recombinant proteins; Related news: HMGB1, a biomarker and therapeutic target in COVID-19 |
| 翻译后修饰 | Found both in glycosylated and nonglycosylated forms. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG70167 Mouse IL17 / IL17A recombinant protein (Active) (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70167 Mouse IL17 / IL17A recombinant protein (Active) (His-tagged, C-ter).
