ARG70495
Mouse TNFR2 recombinant protein (His-tagged)
Mouse TNFR2 recombinant protein (His-tagged) for SDS-PAGE
概述
| 产品描述 | CHO expressed, His-tagged Mouse TNFR2 recombinant protein. |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | TNFR2 |
| 物种 | Mouse |
| A.A. 序列 | Met1 - Gly258 |
| 表达系统 | CHO |
| Protein Full name | Tumor necrosis factor receptor superfamily member 1B |
| 別名 | TNFRSF1B; TNF Receptor Superfamily Member 1B; TNFBR; P75; TNF-R-II; TNF-R75; TNFR80; CD120b; TNFR2; Tumor Necrosis Factor Receptor Superfamily Member 1B; Tumor Necrosis Factor Receptor Type II; Tumor Necrosis Factor Receptor 2; P80 TNF-Alpha Receptor; TNF-RII; TNF-R2; Tumor Necrosis Factor Receptor Superfamily, Member 1B; Tumor Necrosis Factor Binding Protein 2; Tumor Necrosis Factor Beta Receptor; P75 TNF Receptor; CD120b Antigen; Etanercept; P75TNFR; TNFR-II; TNFR1B; TBPII |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | TNFRSF1B |
|---|---|
| 全名 | TNF Receptor Superfamily Member 1B |
| 背景介绍 | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008] |
| 生物功能 | Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. [Uniprot] |
