概述

产品描述	ARG83644 Rat RANTES ELISA Kit is an Enzyme Immunoassay kit for the quantification of Rat RANTES in serum, plasma (heparin, EDTA, citrate) and cell culture supernatants.
反应物种	Rat
应用	ELISA
靶点名称	RANTES
偶联标记	HRP
偶联标记说明	Substrate: TMB and read at 450 nm.
灵敏度	5 pg/ml
样品类型	Serum, plasma (heparin, EDTA, citrate) and cell culture supernatants.
标准范围	15.6 - 1000 pg/ml
样本量	100 μl
精确	Intra-Assay CV: < 10% Inter-Assay CV: < 10%
別名	CCL5; C-C Motif Chemokine Ligand 5; TCP228; SIS-Delta; D17S136E; RANTES; SCYA5; SISd; Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 5; Eosinophil Chemotactic Cytokine; Chemokine (C-C Motif) Ligand 5; T-Cell Specific Protein P288; Beta-Chemokine RANTES; C-C Motif Chemokine 5; MGC17164; EoCP; Small Inducible Cytokine A5 (RANTES); T-Cell Specific RANTES Protein; T-Cell-Specific Protein RANTES; T Cell-Specific Protein P228; Small-Inducible Cytokine A5

应用说明

检测时间	4 hours

属性

形式	96 well
存放说明	Store the kit at 4°C, -20°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 81780 Rat CCL5
基因名称	CCL5
全名	C-C Motif Chemokine Ligand 5
背景介绍	This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
生物功能	May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. [Uniprot]
细胞定位	Secreted. [Uniprot]
翻译后修饰	Disulfide bond, Glycoprotein, Oxidation. [Uniprot]

检测图片 (1) Click the Picture to Zoom In