ARG53742
anti-AGR2 + AGR3 antibody [AGR3.4]
anti-AGR2 + AGR3 antibody [AGR3.4] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Cancer antibody; Signaling Transduction antibody
概述
| 产品描述 | Mouse Monoclonal antibody [AGR3.4] recognizes AGR2 + AGR3 |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, IHC-P, WB |
| 特异性 | The clone AGR3.4 recognizes the PLMII epitope of AGR3 (AG3) and AGR2 (AG2) proteins (19-20 kDa); secreted cytoplasmic proteins which can serve as markers of carcinogenesis. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | AGR3.4 |
| 同位型 | IgG1 |
| 靶点名称 | AGR2 + AGR3 |
| 抗原物种 | Human |
| 抗原 | Purified human AGR3 protein |
| 偶联标记 | Un-conjugated |
| 別名 | Anterior gradient protein 2 homolog; Secreted cement gland protein XAG-2 homolog; hAG-2; GOB-4; HAG-2; HPC8; PDIA17; HEL-S-116; AG-2; XAG-2; AG2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | WB and ICC/IF: Positive control: T47D. Negative control: H1299 IHC-P: Positive control: Human colon |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from ascites by protein-A affinity chromatography. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O95994 Human Anterior gradient protein 2 homolog |
|---|---|
| 基因名称 | AGR2 |
| 全名 | anterior gradient 2 |
| 背景介绍 | AGR2 (Anterior Gradient 2), also known as AG2 (hAG-2, HAG2 in human), or GOB-4, and AGR3 (Anterior Gradient 3), also known as AG3 (hAG-3, HAG3 in human), or BCMP11, are secreted cytoplasmic proteins which are involved in metastasis induction and p53 tumour supressor inhibition. They may serve as molecular markers and potential therapeutic targets for hormone-responsive breast tumours; AGR2 was reported also as a marker of other carcinomas. Xenopus homolog of these proteins is associated with anteroposterior fate determination during early development. |
| 生物功能 | Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. [UniProt] |
| 研究领域 | Cancer antibody; Signaling Transduction antibody |
| 预测分子量 | 20 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG53742 anti-AGR2 + AGR3 antibody [AGR3.4] WB image
Western blot: 1) H1229 cell lysate, and 2) T47D cell lysate stained with ARG53742 anti-AGR2 + AGR3 antibody [AGR3.4].
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ARG53742 anti-AGR2 + AGR3 antibody [AGR3.4] IHC-P image
Immunohistochemistry: Human colon (paraffin sections) stained with ARG53742 anti-AGR2 + AGR3 antibody [AGR3.4].
