ARG54448
anti-ANP32A / PHAP1 antibody
anti-ANP32A / PHAP1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody; Signaling Transduction antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ANP32A / PHAP1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 特异性 | This antibody recognizes Human, Mouse and Rat PHAP1 (32 kDa), and does not cross-react with PHAP I2a or PHAP3. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ANP32A / PHAP1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the C-terminus of Human PHAP1 (P39687). |
| 偶联标记 | Un-conjugated |
| 別名 | Putative HLA-DR-associated protein I; Potent heat-stable protein phosphatase 2A inhibitor I1PP2A; Mapmodulin; pp32; PHAPI; C15orf1; PP32; I1PP2A; PHAP1; Acidic nuclear phosphoprotein pp32; LANP; Acidic leucine-rich nuclear phosphoprotein 32 family member A; HPPCn; MAPM; Leucine-rich acidic nuclear protein |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Raji, Mouse testis, Rat testis and Mouse small intestine |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Immunoaffinity chroma-tography |
| 缓冲液 | PBS (pH 7.4) and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ANP32A |
| 全名 | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A |
| 背景介绍 | The PHAP proteins (tumor suppressor putative HLA-DR associated proteins) are important regulators of mitochondrial apoptosis. PHAP facilitates apoptosome-mediated caspase-9 activation to stimulate the mitochondrial apoptosis pathway. In addition, PHAP opposes both Ras- and myc- mediated cell transformation. |
| 生物功能 | Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression. [UniProt] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody; Signaling Transduction antibody |
| 预测分子量 | 29 kDa |
| 翻译后修饰 | Phosphorylated on serine residues. The N-terminus is blocked. Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity). |
检测图片 (2) Click the Picture to Zoom In
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ARG54448 anti-ANP32A / PHAP1 antibody IHC image
Immunohistochemistry: Mouse small intestine stained with ARG54448 anti-ANP32A / PHAP1 antibody at 2 μg/ml dilution.
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ARG54448 anti-ANP32A / PHAP1 antibody WB image
Western blot: A) Raji, B) Mouse testis and C) Mouse testis lysates stained with ARG54448 anti-ANP32A / PHAP1 antibody at 1 μg/ml dilution.
