ARG54433
anti-ARTS antibody
anti-ARTS antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody; Metabolism antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ARTS |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 特异性 | This antibody recognizes human ARTS (Apoptosis Related Protein in TGF- Signaling Pathway), a novel mito-chondrial septin-like protein. ARTS translocates to the cell nucleus when apoptosis occurs. It enhances apoptosis induced by TGF- and other inducers of apoptosis, such as TNF- and Fas ligand. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ARTS |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around aa. 3-14 of Human ARTS. |
| 偶联标记 | Un-conjugated |
| 別名 | Apoptosis-related protein in the TGF-beta signaling pathway; PNUTL2; ARTS; Peanut-like protein 2; Cell division control-related protein 2; CE5B3; Brain protein H5; CE5B3 beta; Septin-4; BRADEION; H5; MART; Bradeion beta; hucep-7; hCDCREL-2; SEP4; Cerebral protein 7 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Human lung, kidney and spleen |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Immunoaffinity chroma-tography |
| 缓冲液 | PBS (pH 7.4) and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SEPT4 |
| 全名 | septin 4 |
| 背景介绍 | This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010] |
| 生物功能 | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli. [UniProt] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody; Metabolism antibody |
| 预测分子量 | 55 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG54433 anti-ARTS antibody WB image
Western Blot: 1:human lung; 2:spleen; 3:kidney stained with ARG54433 anti-ARTS antibody at 2 μg/ml dilution.
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ARG54433 anti-ARTS antibody IHC image
Immunohistochemistry: human lung tissue stained with ARG54433 anti-ARTS antibody at 2 μg/ml dilution.
