ARG44588
anti-ATF4 antibody
anti-ATF4 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ATF4 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 靶点名称 | ATF4 |
| 抗原物种 | Human |
| 抗原 | Synthesized peptide from Human ATF4 |
| 抗原表位 | IgG |
| 偶联标记 | Un-conjugated |
| Protein Full name | Cyclic AMP-dependent transcription factor ATF-4 |
| 別名 | ATF4; Activating Transcription Factor 4; CREB-2; TAXREB67; TXREB; Tax-Responsive Enhancer Element-Binding Protein 67; Cyclic AMP-Dependent Transcription Factor ATF-4; Cyclic AMP-Responsive Element-Binding Protein 2; CAMP-Dependent Transcription Factor ATF-4; CAMP-Responsive Element-Binding Protein 2; Tax-Responsive Enhancer Element B67; CREB2; Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67); CAMP Response Element-Binding Protein 2; DNA-Binding Protein TAXREB67; TaxREB67 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 实际分子量 | 50 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 纯度 | PBS (pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 缓冲液 | 0.02% Sodium azide |
| 抗菌剂 | 50% Glycerol |
| 稳定剂 | 4% Trehalose |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ATF4 |
| 全名 | Activating Transcription Factor 4 |
| 背景介绍 | This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011] |
| 生物功能 | Transcription factor that binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') and displays two biological functions, as regulator of metabolic and redox processes under normal cellular conditions, and as master transcription factor during integrated stress response (ISR). |
| 细胞定位 | Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus |
| 产品亮点 | Related news: Disulfidptosis markers; |
| 预测分子量 | 39 kDa |
| 翻译后修饰 | Acetylation, Hydroxylation, Isopeptide bond, Phosphoprotein, Ubl conjugation |
检测图片 (4) Click the Picture to Zoom In
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ARG44588 anti-ATF4 antibody IHC-P image
Immunohistochemistry: Mouse kidney stained with ARG44588 anti-ATF4 antibody.
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ARG44588 anti-ATF4 antibody ICC/IF image
Immunofluorescence: 293 stained with ARG44588 anti-ATF4 antibody.
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ARG44588 anti-ATF4 antibody WB image
Western blot: HeLa stained with ARG44588 anti-ATF4 antibody.
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ARG44588 anti-ATF4 antibody WB image
Western blot: 3T3 stained with ARG44588 anti-ATF4 antibody.
