ARG45145
anti-BCAR3 antibody
anti-BCAR3 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes BCAR3 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | BCAR3 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to C-terminal region of human BCAR3. |
| 偶联标记 | Un-conjugated |
| 別名 | BCAR3; Breast cancer anti-estrogen resistance protein 3; Breast cancer anti-estrogen resistance protein 3; Novel SH2-containing protein 2; SH2 domain-containing protein 3B; BCAR3; NSP2; SH2D3B; UNQ271/PRO308; AND-34; MIG7; BCAR3, NSP Family Adaptor Protein; Migration Inducting Gene-7; DJ1033H22.2 (Breast Cancer Anti-Estrogen Resistance 3); Breast Cancer Antiestrogen Resistance 3 Protein; Epididymis Secretory Sperm Binding Protein |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 93 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O75815 Human Breast cancer anti-estrogen resistance protein 3 Swiss-port # Q9QZK2 Mouse Breast cancer anti-estrogen resistance protein 3 |
|---|---|
| 基因名称 | BCAR3 |
| 全名 | Breast cancer anti-estrogen resistance protein 3 |
| 背景介绍 | Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] |
| 生物功能 | Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers. [UniProt] |
| 细胞定位 | Cytoplasm; Cell junction, focal adhesion; Secreted. [UniProt] |
| 预测分子量 | 93 kDa |
| 翻译后修饰 | Acetylation; Methylation; Phosphoprotein. [UniProt] |
检测图片 (4) Click the Picture to Zoom In
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ARG45145 anti-BCAR3 antibody IHC-P image
Immunohistochemistry: Human tonsil stained with ARG45145 anti-BCAR3 antibody at 1 μg/ml dilution.
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ARG45145 anti-BCAR3 antibody WB image
Western blot: HEPG2 stained with ARG45145 anti-BCAR3 antibody at 0.5 μg/ml dilution.
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ARG45145 anti-BCAR3 antibody IHC-P image
Immunohistochemistry: Rat spleen stained with ARG45145 anti-BCAR3 antibody at 1 μg/ml dilution.
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ARG45145 anti-BCAR3 antibody IHC-P image
Immunohistochemistry: Mouse lymphaden stained with ARG45145 anti-BCAR3 antibody at 1 μg/ml dilution.
