ARG45340
anti-C5a / Complement C5 antibody [7L11]
anti-C5a / Complement C5 antibody [7L11] for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Mouse
概述
| 产品描述 | Rat Monoclonal antibody [7L11] recognizes C5a / Complement C5 |
|---|---|
| 反应物种 | Ms |
| 应用 | IHC-P, WB |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | 7L11 |
| 同位型 | IgG2 |
| 靶点名称 | C5a / Complement C5 |
| 抗原物种 | Mouse |
| 抗原 | Recombinant Mouse C5a / Complement C5. |
| 偶联标记 | Un-conjugated |
| 別名 | ECLZB; CPAMD4; Complement C5; C5D; C5b; C5a; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Powder |
|---|---|
| 纯化 | Protein G/A chromatography |
| 缓冲液 | PBS |
| 复溶 | PBS |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P30993 Mouse C5a anaphylatoxin chemotactic receptor 1 |
|---|---|
| 基因名称 | C5 |
| 全名 | complement component 5 |
| 背景介绍 | The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008] |
| 生物功能 | Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. [UniProt] |
| 细胞定位 | Membrane attack complex; Secreted. [UniProt] |
| 预测分子量 | 188 kDa |
| 翻译后修饰 | Cleavage on pair of basic residues; Disulfide bond; Glycoprotein. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG45340 anti-C5a / Complement C5 antibody [7L11] IHC-P image
Immunohistochemistry: Mouse kidney stained with ARG45340 anti-C5a / Complement C5 antibody [7L11].
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ARG45340 anti-C5a / Complement C5 antibody [7L11] WB image
Western blot: Mouse serum stained with ARG45340 anti-C5a / Complement C5 antibody [7L11].
