ARG22081
anti-CD103 / Integrin alpha E antibody [2E7]
anti-CD103 / Integrin alpha E antibody [2E7] for Cellular activation ,Flow cytometry,IHC-Frozen sections,Immunoprecipitation and Mouse
概述
| 产品描述 | Hamster Monoclonal antibody [2E7] recognizes CD103 / Integrin alpha E |
|---|---|
| 反应物种 | Ms |
| 应用 | Cell-Act , FACS, IHC-Fr, IP |
| 特异性 | Mouse CD103 |
| 宿主 | Hamster |
| 克隆 | Monoclonal |
| 克隆号 | 2E7 |
| 同位型 | IgG2 |
| 靶点名称 | CD103 / Integrin alpha E |
| 抗原物种 | Mouse |
| 抗原 | C57BL/6J Mouse intestinal intraepithelial lymphocytes (IEL) |
| 偶联标记 | Un-conjugated |
| 別名 | CD103; HUMINAE; Integrin alpha-E; Mucosal lymphocyte 1 antigen; CD antigen CD103; HML-1 antigen; Integrin alpha-IEL |
应用说明
| 应用建议 |
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| 应用说明 | Cellular activation: This clone up-regulates CD5 surface expression on CD8 alpha/beta+ gut IEL cells (gut intraepithelial lymphocytes) * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | BBS (pH 8.2) |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ITGAE |
| 全名 | integrin alpha E, epithelial-associated |
| 背景介绍 | Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008] |
| 生物功能 | Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. [UniProt] |
| 预测分子量 | 130 kDa |
