ARG20962
anti-CD106 / VCAM1 antibody [1.G11B1]
anti-CD106 / VCAM1 antibody [1.G11B1] for Blocking,ELISA,Flow cytometry,ICC/IF,IHC-Frozen sections,Immunoprecipitation,Western blot and Human,Pig
概述
| 产品描述 | Mouse Monoclonal antibody [1.G11B1] recognizes CD106 / VCAM1 |
|---|---|
| 反应物种 | Hu, Pig |
| 应用 | BL, ELISA, FACS, ICC/IF, IHC-Fr, IP, WB |
| 特异性 | Human/Porcine CD106. The clone 1.G11B1 inhibits in vitro binding of lymphocytes and monocytes to VCAM-1 on stimulated endothelium. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 1.G11B1 |
| 同位型 | IgG1, kappa |
| 靶点名称 | CD106 / VCAM1 |
| 抗原物种 | Human |
| 偶联标记 | Un-conjugated |
| 別名 | CD106; INCAM-100; Vascular cell adhesion protein 1; VCAM-1; CD antigen CD106; V-CAM 1 |
应用说明
| 应用建议 |
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| 应用说明 | WB: Under non-reducing condition. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | BBS (pH 8.2) |
| 浓度 | 0.1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | VCAM1 |
| 全名 | vascular cell adhesion molecule 1 |
| 背景介绍 | This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010] |
| 生物功能 | Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. [UniProt] |
| 预测分子量 | 81 kDa |
| 翻译后修饰 | Sialoglycoprotein. |
检测图片 (1) Click the Picture to Zoom In
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ARG20962 anti-CD106 / VCAM1 antibody [1.G11B1] FACS image
Flow Cytometry: TNFα stimulated Human endothelial cell line HUV-EC-C was stained with ARG20962 anti-CD106 / VCAM1 antibody [1.G11B1] followed by ARG21884 Goat anti-Mouse IgG1 antibody (FITC) (pre-adsorbed).
