ARG20964
anti-CD106 / VCAM1 antibody [1.G11B1] (Biotin)
anti-CD106 / VCAM1 antibody [1.G11B1] (Biotin) for Blocking,ELISA,Flow cytometry,ICC/IF,IHC-Frozen sections,Western blot and Human,Pig
概述
| 产品描述 | Biotin-conjugated Mouse Monoclonal antibody [1.G11B1] recognizes CD106 / VCAM1 |
|---|---|
| 反应物种 | Hu, Pig |
| 应用 | BL, ELISA, FACS, ICC/IF, IHC-Fr, WB |
| 特异性 | Human/Porcine CD106. The clone 1.G11B1 inhibits in vitro binding of lymphocytes and monocytes to VCAM-1 on stimulated endothelium. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 1.G11B1 |
| 同位型 | IgG1, kappa |
| 靶点名称 | CD106 / VCAM1 |
| 抗原物种 | Human |
| 偶联标记 | Biotin |
| 別名 | CD106; INCAM-100; Vascular cell adhesion protein 1; VCAM-1; CD antigen CD106; V-CAM 1 |
应用说明
| 应用建议 |
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | WB: Under non-reducing condition. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | PBS and 0.1% Sodium azide. |
| 抗菌剂 | 0.1% Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | VCAM1 |
| 全名 | vascular cell adhesion molecule 1 |
| 背景介绍 | This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010] |
| 生物功能 | Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. [UniProt] |
| 预测分子量 | 81 kDa |
| 翻译后修饰 | Sialoglycoprotein. |
