ARG42059
anti-CD106 / VCAM1 antibody
anti-CD106 / VCAM1 antibody for Flow cytometry,ICC/IF,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
参考文献1
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CD106 / VCAM1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, ICC/IF, IHC-Fr, IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CD106 / VCAM1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human CD106 / VCAM1. |
| 偶联标记 | Un-conjugated |
| 別名 | CD106; INCAM-100; Vascular cell adhesion protein 1; VCAM-1; CD antigen CD106; V-CAM 1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||||||
| 阳性对照 | Mouse kidney | ||||||||||||||
| 实际分子量 | ~ 100 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | VCAM1 |
| 全名 | vascular cell adhesion molecule 1 |
| 背景介绍 | This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010] |
| 生物功能 | Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 81 kDa |
| 翻译后修饰 | Sialoglycoprotein. [UniProt] |
检测图片 (4) Click the Picture to Zoom In
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ARG42059 anti-CD106 / VCAM1 antibody IHC-Fr image
Immunohistochemistry: Mouse endothelial stained with ARG42059 anti-CD106 / VCAM1 antibody at 1:100 dilution.
From Rui Fan et al. Biochim Biophys Acta Mol Cell Biol Lipids. (2023), doi: 10.1016/j.bbalip.2023.159330, Fig. 2B.
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ARG42059 anti-CD106 / VCAM1 antibody ICC/IF image
Immunofluorescence: K562 cells stained with ARG42059 anti-CD106 / VCAM1 antibody.
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ARG42059 anti-CD106 / VCAM1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human tonsil tissue stained with ARG42059 anti-CD106 / VCAM1 antibody.
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ARG42059 anti-CD106 / VCAM1 antibody WB image
Western blot: Mouse kidney lysate stained with ARG42059 anti-CD106 / VCAM1 antibody.
文献引用
Severe hypertriglyceridemia caused by Gpihbp1 deficiency facilitates vascular remodeling through increasing endothelial activation and oxidative stress
IHC-Fr / Mouse
