ARG66059
anti-CD120a / TNFR1 antibody
anti-CD120a / TNFR1 antibody for ELISA,Neutralizing,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CD120a / TNFR1 |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA, Neut, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CD120a / TNFR1 |
| 抗原物种 | Human |
| 抗原 | E. coli derived recombinant Human TNF Receptor I. (MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESGSF TASENHLRHC LSCSKCRKEM GQVEISSCTV DRDTVCGCRK NQYRHYWSEN LFQCFNCSLC LNGTVHLSCQ EKQNTVCTCH AGFFLRENEC VSCSNCKKSL ECTKLCLPQI EN) |
| 偶联标记 | Un-conjugated |
| 別名 | TNF-R; p60; TNFAR; CD antigen CD120a; TNFR55; TBP1; TNF-RI; TNFR1-d2; Tumor necrosis factor receptor superfamily member 1A; FPF; TNFR60; CD120a; TNFR1; p55; TNF-R55; TNF-R-I; MS5; TNFR-I; Tumor necrosis factor receptor 1; TBPI; Tumor necrosis factor receptor type I; TNF-R1; p55-R |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.2) |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P19438 Human Tumor necrosis factor receptor superfamily member 1A |
|---|---|
| 基因名称 | TNFRSF1A |
| 全名 | tumor necrosis factor receptor superfamily, member 1A |
| 背景介绍 | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008] |
| 生物功能 | Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. [UniProt] |
| 预测分子量 | 50 kDa |
| 翻译后修饰 | The soluble form is produced from the membrane form by proteolytic processing. |
检测图片 (3) Click the Picture to Zoom In
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ARG66059 anti-CD120a / TNFR1 antibody WB image
Western blot: 250 - 0.24 ng of Human sTNF-receptor stained with ARG66059 anti-CD120a / TNFR1 antibody, under reducing conditions.
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ARG66059 anti-CD120a / TNFR1 antibody standard curve image
Sandwich ELISA: ARG66059 anti-CD120a / TNFR1 antibody as a capture antibody at 0.5 - 2.0 µg/ml combined with ARG66060 anti-TNF Receptor I antibody (Biotin) as a detection antibody. Results of a typical standard run with optical density reading at 405 - 650 nm.
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ARG66059 anti-CD120a / TNFR1 antibody WB image
Western blot: 250 - 0.24 ng of Human sTNF-receptor stained with ARG66059 anti-CD120a / TNFR1 antibody, under non-reducing conditions.
