ARG42270
anti-CD123 / IL3RA antibody [6H6] (FITC)
anti-CD123 / IL3RA antibody [6H6] (FITC) for Flow cytometry and Human
概述
| 产品描述 | FITC-conjugated Mouse Monoclonal antibody [6H6] recognizes CD123 / IL3RA |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody 6H6 recognizes an extracellular epitope of CD123 (interleukin 3 receptor alpha), a 60-70 kDa transmembrane protein expressed by myeloid precursors, megakaryocytes, macrophages, dendritic cells, mast cells, basophils, and some B cells. This antibody does not inhibit IL-3 binding to its receptor. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 6H6 |
| 同位型 | IgG1 |
| 靶点名称 | CD123 / IL3RA |
| 抗原物种 | Human |
| 抗原 | IL3 receptor alpha chain expressed on the surface of transiently transfected COS cells. |
| 偶联标记 | FITC |
| 別名 | IL-3R subunit alpha; CD123; CD antigen CD123; IL3RAY; IL-3R-alpha; IL3RY; IL3RX; IL3R; IL-3RA; IL-3 receptor subunit alpha; hIL-3Ra; Interleukin-3 receptor subunit alpha |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P26951 Human Interleukin-3 receptor subunit alpha |
|---|---|
| 基因名称 | IL3RA |
| 全名 | interleukin 3 receptor, alpha (low affinity) |
| 背景介绍 | The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012] |
| 生物功能 | This is a receptor for interleukin-3. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 43 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG42270 anti-CD123 / IL3RA antibody [6H6] (FITC) FACS image
Flow Cytometry: Human peripheral blood stained with ARG42270 anti-CD123 / IL3RA antibody [6H6] (FITC) and anti-HLA DR antibody (APC).
