ARG23322
anti-CD130 / gp130 antibody [B-K5] (azide free)
anti-CD130 / gp130 antibody [B-K5] (azide free) for Flow cytometry,Functional study and Human
概述
| 产品描述 | Azide free Mouse Monoclonal antibody [B-K5] recognizes CD130 / gp130 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, FuncSt |
| 特异性 | This antibody recognizes Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | B-K5 |
| 同位型 | IgG1 |
| 靶点名称 | CD130 / gp130 |
| 抗原物种 | Human |
| 抗原 | Natural soluble gp130 |
| 偶联标记 | Un-conjugated |
| 別名 | CDw130; CD130; CDW130; Interleukin-6 signal transducer; CD antigen CD130; IL-6RB; Membrane glycoprotein 130; GP130; Oncostatin-M receptor subunit alpha; IL-6R subunit beta; Interleukin-6 receptor subunit beta; gp130; IL-6 receptor subunit beta; IL-6R-beta |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | Sterile-filtered through 0.22 µm. |
| 缓冲液 | PBS |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P40189 Human Interleukin-6 receptor subunit beta |
|---|---|
| 基因名称 | IL6ST |
| 全名 | interleukin 6 signal transducer |
| 背景介绍 | The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014] |
| 生物功能 | Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events. [UniProt] |
| 预测分子量 | 104 kDa |
| 翻译后修饰 | Phosphorylation of Ser-782 down-regulates cell surface expression. Heavily N-glycosylated (PubMed:11098061, PubMed:16335952, PubMed:19159218, PubMed:19139490, PubMed:11251120). Glycosylation is required for protein stability and localization in plasma membrane but not for ligand binding (PubMed:19915009). [UniProt] |
