ARG42320
anti-CD134 / OX40 antibody [Ber-ACT35] (APC)
anti-CD134 / OX40 antibody [Ber-ACT35] (APC) for Flow cytometry and Human,Primates
概述
| 产品描述 | APC-conjugated Mouse Monoclonal antibody [Ber-ACT35] recognizes CD134 / OX40 |
|---|---|
| 反应物种 | Hu, NHuPrm |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody Ber-ACT35 (also known as ACT35) recognizes an extracellular epitope of CD134 (TNFRSF4, OX40), an approximately 50 kDa type I transmembrane glycoprotein expressed on activated T cells. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | Ber-ACT35 |
| 同位型 | IgG1, kappa |
| 靶点名称 | CD134 / OX40 |
| 抗原物种 | Human |
| 抗原 | HTLV 1-transformed HUT-102 cells. |
| 偶联标记 | APC |
| 別名 | CD134; TAX transcriptionally-activated glycoprotein 1 receptor; TXGP1L; OX40L receptor; Tumor necrosis factor receptor superfamily member 4; OX40; CD antigen CD134; IMD16; ACT35 antigen; ACT35 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P43489 Human Tumor necrosis factor receptor superfamily member 4 |
|---|---|
| 基因名称 | TNFRSF4 |
| 全名 | tumor necrosis factor receptor superfamily, member 4 |
| 背景介绍 | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008] |
| 生物功能 | Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity. (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 29 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG42320 anti-CD134 / OX40 antibody [Ber-ACT35] (APC) FACS image
Flow Cytometry: Human PHA stimulated peripheral blood mononuclear cells stained with ARG42320 anti-CD134 / OX40 antibody [Ber-ACT35] (APC) at 10 µl / 10^6 cells in 100 µl of cell suspension.
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ARG42320 anti-CD134 / OX40 antibody [Ber-ACT35] (APC) FACS image
Flow Cytometry: Human PHA stimulated peripheral blood mononuclear cells stained with ARG42320 anti-CD134 / OX40 antibody [Ber-ACT35] (APC) at 10 µl / 10^6 cells in 100 µl of cell suspension and ARG53801 anti-CD25 antibody [MEM-181] (PE) at 20 µl / 100 µl of peripheral whole blood.
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ARG42320 anti-CD134 / OX40 antibody [Ber-ACT35] (APC) FACS image
Flow Cytometry: Separation of Human CD134 positive CD25 positive cells (red-filled) from CD134 negative CD25 negative cells (black-dashed). Human PHA stimulated peripheral blood mononuclear cells stained with ARG42320 anti-CD134 / OX40 antibody [Ber-ACT35] (APC) at 10 µl / 10^6 cells in 100 µl of cell suspension.
