ARG42319
anti-CD137 antibody [4B4-1] (APC)
anti-CD137 antibody [4B4-1] (APC) for Flow cytometry and Human,Primates
概述
| 产品描述 | APC-conjugated Mouse Monoclonal antibody [4B4-1] recognizes CD137 |
|---|---|
| 反应物种 | Hu, NHuPrm |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody 4B4-1 recognizes an extracellular conformational epitope on CD137, an approximately 40 kDa type I transmembrane protein of the TNFR family expressed mainly on activated T cells. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 4B4-1 |
| 同位型 | IgG1, kappa |
| 靶点名称 | CD137 |
| 抗原物种 | Human |
| 抗原 | Recombinant Human CD137 ectodomain. |
| 偶联标记 | APC |
| 別名 | ILA; CD137; T-cell antigen 4-1BB homolog; CDw137; T-cell antigen ILA; 4-1BB; CD antigen CD137; Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q07011 Human Tumor necrosis factor receptor superfamily member 9 |
|---|---|
| 基因名称 | TNFRSF9 |
| 全名 | tumor necrosis factor receptor superfamily, member 9 |
| 背景介绍 | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008] |
| 生物功能 | Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 28 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG42319 anti-CD137 antibody [4B4-1] (APC) FACS image
Flow Cytometry: Human PHA stimulated peripheral blood mononuclear cell suspension stained with ARG42319 anti-CD137 antibody [4B4-1] (APC) at 10 µl / 10^6 cells in 100 µl of cell suspension.
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ARG42319 anti-CD137 antibody [4B4-1] (APC) FACS image
Flow Cytometry: Human peripheral blood mononulcear cells stained with ARG42319 anti-CD137 antibody [4B4-1] (APC) at 10 µl / 10^6 cells in 100 µl of cell suspension and ARG53801 anti-CD25 antibody [MEM-181] (PE) at 20 µl / 10^6 cells in 100 µl of cell suspension.
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ARG42319 anti-CD137 antibody [4B4-1] (APC) FACS image
Flow Cytometry: Human PHA stimulated peripheral blood mononuclear cell suspension. Separation of cells stained with ARG42319 anti-CD137 antibody [4B4-1] (APC) at 10 µl / 10^6 cells in 100 µl of cell suspension (red-filled) from cells stained with ARG65336 Mouse IgG1 Kappa Isotype Control antibody [MOPC-21] (APC) at 1 µg/ml dilution (black-dashed).
