ARG42346
anti-CD146 antibody [P1H12] (PE)
anti-CD146 antibody [P1H12] (PE) for Flow cytometry and Human,Mouse,Dog,Rabbit
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [P1H12] recognizes CD146 |
|---|---|
| 反应物种 | Hu, Ms, Dog, Rb |
| 不反应物种 | Rat |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody P1H12 recognizes an extracellular epitope of CD146, a 118 kDa transmembrane glycoprotein expressed on epithelial and endothelial cells, fibroblasts, multipotent mesenchymal stromal cells, melanoma cells, activated T cells and activated keratinocytes. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | P1H12 |
| 同位型 | IgG1 |
| 靶点名称 | CD146 |
| 抗原物种 | Human |
| 抗原 | Cultured Human umbilical cells. |
| 偶联标记 | PE |
| 別名 | Cell surface glycoprotein P1H12; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; Cell surface glycoprotein MUC18; Melanoma cell adhesion molecule; CD146; MUC18; CD antigen CD146; S-endo 1 endothelial-associated antigen |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MCAM |
| 全名 | melanoma cell adhesion molecule |
| 生物功能 | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 72 kDa |
