ARG62733
anti-CD147 antibody [MEM-M6/1] (FITC)
anti-CD147 antibody [MEM-M6/1] (FITC) for Flow cytometry and Human
Cancer antibody; Immune System antibody; Metabolism antibody; Neuroscience antibody
概述
| 产品描述 | FITC-conjugated Mouse Monoclonal antibody [MEM-M6/1] recognizes CD147 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The clone MEM-M6/1 recognizes an epitope in the N-terminal Ig domain (D1) of CD147 (Neurothelin), a 50-60 kDa type I transmembrane glycoprotein primarily expressed on all leukocytes, red blood cells, platelets and endothelial cells; it is not expressed by resting lymphocytes. MEM-M6/1 is a high-affinity antibody capable of binding to unstimulated peripheral blood T cells. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | MEM-M6/1 |
| 同位型 | IgG1 |
| 靶点名称 | CD147 |
| 抗原物种 | Human |
| 抗原 | Protein A-CR purified soluble recombinant form of CD147, CD147Rg, which consists of the cDNA coding for the hinge region, CH2-and CH3 domain of human IgG1 (CD147Rg is secreted by transfectants as a dimer). |
| 偶联标记 | FITC |
| 別名 | OK; Tumor cell-derived collagenase stimulatory factor; Leukocyte activation antigen M6; TCSF; Extracellular matrix metalloproteinase inducer; OK blood group antigen; CD147; Basigin; M6; EMMPRIN; Collagenase stimulatory factor; CD antigen CD147; 5F7 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | BSG |
| 全名 | basigin (Ok blood group) |
| 背景介绍 | CD147 (basigin, neurothelin, OX-47, 5A11, CE9, M6) also known as EMMPRIN (extracellular matrix metalloproteinase inducer) or TCSF (tumour cell-derived collagenase-stimulatory factor) is an ubiquitously expressed cell surface protein with multiple glycosylated forms. The highest level of CD147 expression is on metabolically active cells, such as lymphoblasts, inflammatory cells, brown adipocytes and malignant tumour cells. CD147 has multiple functions, including facilitating of cell surface expression of monocarboxylate transporter proteins and extracellular matrix metalloproteinases, regulation of integrin functions, it plays roles in cell development and activation, fetal development or retinal function. |
| 生物功能 | Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. [UniProt] |
| 研究领域 | Cancer antibody; Immune System antibody; Metabolism antibody; Neuroscience antibody |
| 预测分子量 | 42 kDa |
| 翻译后修饰 | N-glycosylated. |
检测图片 (1) Click the Picture to Zoom In
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ARG62733 anti-CD147 antibody [MEM-M6/1] (FITC) FACS image
Flow Cytometry: Human peripheral blood stained with ARG62733 anti-CD147 antibody [MEM-M6/1] (FITC).
