ARG44592
anti-CD160 antibody [BY55] (FITC)
anti-CD160 antibody [BY55] (FITC) for Flow cytometry and Human
概述
| 产品描述 | FITC-conjugated Mouse Monoclonal antibody recognizes CD160 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | BY55 |
| 同位型 | IgM kappa |
| 靶点名称 | CD160 |
| 抗原物种 | Human |
| 偶联标记 | FITC |
| 別名 | CD160; CD160 Molecule; BY55; CD160 Antigen; NK28; NK1; Natural Killer Cell Receptor BY55; Natural Killer Cell Receptor, Immunoglobulin Superfamily Member; CD160-Delta Ig |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified antibody is conjugated with fluorescein isothiocyanate (FITC), and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography. |
| 缓冲液 | PBS (pH 8.0) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CD160 |
| 全名 | CD160 molecule |
| 背景介绍 | CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008] |
| 生物功能 | Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells. [UniProt] |
| 细胞定位 | Cell membrane, Membrane, Secreted. [UniProt] |
| 预测分子量 | 20 kDa |
| 翻译后修饰 | Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG44592 anti-CD160 antibody [BY55] (FITC) FACS image
Flow Cytometry: Human peripheral whole blood stained with ARG44592 anti-CD160 antibody [BY55] (FITC) at 10 μl/ 100 μl dilution.
