ARG42677
anti-CD191 / CCR1 antibody
anti-CD191 / CCR1 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CD191 / CCR1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CD191 / CCR1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human CD191 / CCR1. |
| 偶联标记 | Un-conjugated |
| 別名 | MIP1aR; CD191; C-C chemokine receptor type 1; CKR-1; CKR1; HM145; CD antigen CD191; SCYAR1; CCR-1; C-C CKR-1; CCR1; CMKBR1; RANTES-R; Macrophage inflammatory protein 1-alpha receptor; CC-CKR-1; LD78 receptor; MIP-1alpha-R |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CCR1 |
| 全名 | chemokine (C-C motif) receptor 1 |
| 背景介绍 | This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008] |
| 生物功能 | Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. [UniProt] |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. [UniProt] |
| 预测分子量 | 41 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG42677 anti-CD191 / CCR1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat leg bone tissue stained with ARG42677 anti-CD191 / CCR1 antibody at 1:100 dilution.
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ARG42677 anti-CD191 / CCR1 antibody WB image
Western blot: 25 µg of Mouse lung lysate stained with ARG42677 anti-CD191 / CCR1 antibody at 1:1000 dilution.
