ARG42451
anti-CD193 / CCR3 antibody [5E8] (PE)
anti-CD193 / CCR3 antibody [5E8] (PE) for Flow cytometry and Human
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [5E8] recognizes CD193 / CCR3 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody 5E8 recognizes an extracellular epitope of CD193 (chemokine receptor 3), an approximately 41 kDa protein expressed above all in eosinophils and basophils. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 5E8 |
| 同位型 | IgG2b, kappa |
| 靶点名称 | CD193 / CCR3 |
| 抗原物种 | Human |
| 抗原 | Human CD193 / CCR3. |
| 偶联标记 | PE |
| 別名 | C-C chemokine receptor type 3; CD193; CKR3; CCR-3; Eosinophil eotaxin receptor; CMKBR3; C-C CKR-3; CCR3; CC-CKR-3; CD antigen CD193 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CCR3 |
| 全名 | chemokine (C-C motif) receptor 3 |
| 背景介绍 | The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009] |
| 生物功能 | Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15 (PubMed:7622448, PubMed:8642344, PubMed:8676064). Subsequently transduces a signal by increasing the intracellular calcium ions level (PubMed:8676064). In addition acts as a possible functional receptor for NARS1 (PubMed:30171954). (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection. [UniProt] |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. [UniProt] |
| 预测分子量 | 41 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG42451 anti-CD193 / CCR3 antibody [5E8] (PE) FACS image
Flow Cytometry: Human peripheral blood stained with ARG42451 anti-CD193 / CCR3 antibody [5E8] (PE).
