ARG65393
anti-CD197 / CCR7 antibody [4B12] (PE)
anti-CD197 / CCR7 antibody [4B12] (PE) for Flow cytometry and Mouse
Immune System antibody; Signaling Transduction antibody
概述
| 产品描述 | PE-conjugated Rat Monoclonal antibody [4B12] recognizes CD197 / CCR7 |
|---|---|
| 反应物种 | Ms |
| 应用 | FACS |
| 特异性 | The rat monoclonal antibody 4B12 recognizes murine CD197 / CCR7 (chemokine receptor 7), a 43 kDa Gproteincoupled receptor for chemokines CCL19 and CCL21. |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | 4B12 |
| 同位型 | IgG2a |
| 靶点名称 | CD197 / CCR7 |
| 抗原物种 | Mouse |
| 抗原 | Murine CD197-transfected RBL-2H3 cells |
| 偶联标记 | PE |
| 別名 | C-C chemokine receptor type 7; CD197; CD antigen CD197; CCR-7; CC-CKR-7; BLR2; CMKBR7; C-C CKR-7; MIP-3 beta receptor; EBV-induced G-protein coupled receptor 1; EBI1; Epstein-Barr virus-induced G-protein coupled receptor 1; CDw197 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 0.5 mg/ml |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | Ccr7 |
| 全名 | chemokine (C-C motif) receptor 7 |
| 背景介绍 | CD197 / CCR7 (chemokine receptor 7) is a seven membrane-spanning protein serving as a receptor for chemokines CCL19 and CCL21. It is expressed on most naive T cells, some hematopoietic stem cells, mature dendritic cells, NK cells and some memory T cells and B cells subsets. CD197 plays important roles in development of thymocytes, and regulating the recirculation and homing of lymphocytes and dendritic cells to secondary lymphoid organs. |
| 生物功能 | Receptor for the MIP-3-beta chemokine. [UniProt] |
| 研究领域 | Immune System antibody; Signaling Transduction antibody |
| 预测分子量 | 43 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG65393 anti-CD197 / CCR7 antibody [4B12] (PE) FACS image
Flow Cytometry: Separation of unstained (black) and stained (red) murine splenocytes. Cells were stained with ARG65393 anti-CD197 / CCR7 antibody [4B12] (PE) at 9 µg/ml dilution.
克隆号文献
The autoimmune diabetes locus Idd9 regulates development of type 1 diabetes by affecting the homing of islet-specific T cells.
CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions.
Analysis of the CCR7 expression on murine bone marrow-derived and spleen dendritic cells.
