ARG42342
anti-CD1b antibody [SN13] (PE)
anti-CD1b antibody [SN13] (PE) for Flow cytometry and Human
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [SN13] recognizes CD1b |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody SN13 (also known as K5-1B8) recognizes an extracellular epitope of CD1b, a 44 kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on dendritic cells, Langerhans cells, thymocytes, and T acute lymphoblastic leukemia cells. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | SN13 |
| 同位型 | IgG1, kappa |
| 靶点名称 | CD1b |
| 抗原物种 | Human |
| 抗原 | A cell membrane antigen preparation that was isolated from normal Human thymocytes. |
| 偶联标记 | PE |
| 別名 | T-cell surface glycoprotein CD1b; CD1A; R1; CD antigen CD1b; CD1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CD1B |
| 全名 | CD1b molecule |
| 背景介绍 | This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. [provided by RefSeq, Jul 2008] |
| 生物功能 | Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. [UniProt] |
| 细胞定位 | Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes. [UniProt] |
| 预测分子量 | 37 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG42342 anti-CD1b antibody [SN13] (PE) FACS image
Flow Cytometry: IL-4 and GM-CSF stimulated Human peripheral blood cells stained with ARG42342 anti-CD1b antibody [SN13] (PE).
