ARG42328
anti-CD1c antibody [L161] (APC)
anti-CD1c antibody [L161] (APC) for Flow cytometry and Human
概述
| 产品描述 | APC-conjugated Mouse Monoclonal antibody [L161] recognizes CD1c |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody L161 recognizes an extracellular epitope of CD1c, (R7), a 43 kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells, B and some T cells. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | L161 |
| 同位型 | IgG1, kappa |
| 靶点名称 | CD1c |
| 抗原物种 | Human |
| 抗原 | Human thymocytes. |
| 偶联标记 | APC |
| 別名 | R7; CD antigen CD1c; CD1A; CD1; T-cell surface glycoprotein CD1c; BDCA1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CD1C |
| 全名 | CD1c molecule |
| 背景介绍 | This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008] |
| 生物功能 | Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. [UniProt] |
| 细胞定位 | Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome. Note=Subject to intracellular trafficking between the cell membrane and endosomes. [UniProt] |
| 预测分子量 | 38 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG42328 anti-CD1c antibody [L161] (APC) FACS image
Flow Cytometry: Human peripheral whole blood stained with ARG42328 anti-CD1c antibody [L161] (APC) at 10 µl / 100 µl of peripheral whole blood.
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ARG42328 anti-CD1c antibody [L161] (APC) FACS image
Flow Cytometry: Human lymphocytes stained with ARG42328 anti-CD1c antibody [L161] (APC) at 10 µl / 100 µl of peripheral whole blood and ARG53783 anti-CD19 antibody [LT19] (PE) at 20 µl / 100 µl of peripheral whole blood.
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ARG42328 anti-CD1c antibody [L161] (APC) FACS image
Flow Cytometry: Separation of Human CD1c positive CD19 positive B cells (red-filled) from Human CD1c negative CD19 negative lymphocytes (black-dashed). Human peripheral whole blood stained with ARG42328 anti-CD1c antibody [L161] (APC) at 10 µl / 100 µl of peripheral whole blood.
