ARG65474
anti-CD1c antibody [L161]
anti-CD1c antibody [L161] for CyTOF®-candidate,Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation and Human
Immune System antibody
概述
| 产品描述 | Mouse Monoclonal antibody [L161] recognizes CD1c |
|---|---|
| 反应物种 | Hu |
| 应用 | CyTOF®-candidate, FACS, IHC-P, IP |
| 特异性 | The clone L161 recognizes CD1c, (R7), a 43 kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells, B and some T cells. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | L161 |
| 同位型 | IgG1 |
| 靶点名称 | CD1c |
| 抗原物种 | Human |
| 抗原 | human thymocytes |
| 偶联标记 | Un-conjugated |
| 別名 | R7; CD antigen CD1c; CD1A; CD1; T-cell surface glycoprotein CD1c; BDCA1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from cell culture supernatant by protein-A affinity chromatography. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CD1C |
| 全名 | CD1c molecule |
| 背景介绍 | CD1c (also known as R7 or BDCA1) together with CD1a and b, belongs to group 1 of CD1 antigens. These non-classical MHC-like glycoproteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. The trafficking routes of the particular CD1 types differ and correspond to their ability to bind and present different groups of antigens. CD1c is unique in its ability to present e.g. mycobacterial phosphoketides and polyisoprenoids. CD1c is the only CD1 isoform that has been shown to interact both with alpha/beta and gamma/delta T cells. |
| 生物功能 | Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. [UniProt] |
| 产品亮点 | Related products: CD1c antibodies; Anti-Mouse IgG secondary antibodies; Related news: CyTOF-candidate Antibodies |
| 研究领域 | Immune System antibody |
| 预测分子量 | 38 kDa |
