ARG54264
anti-CD1c antibody [L161] (PE)
anti-CD1c antibody [L161] (PE) for Flow cytometry and Human
Immune System antibody
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [L161] recognizes CD1c |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The clone L161 recognizes CD1c, (R7), a 43 kDa type I glycoprotein associated with beta2-microglobulin. It is expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells, B and some T cells. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | L161 |
| 同位型 | IgG1 |
| 靶点名称 | CD1c |
| 抗原物种 | Human |
| 抗原 | human thymocytes |
| 偶联标记 | PE |
| 別名 | R7; CD antigen CD1c; CD1A; CD1; T-cell surface glycoprotein CD1c; BDCA1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CD1C |
| 全名 | CD1c molecule |
| 背景介绍 | CD1c (also known as R7 or BDCA1) together with CD1a and b, belongs to group 1 of CD1 antigens. These non-classical MHC-like glycoproteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. The trafficking routes of the particular CD1 types differ and correspond to their ability to bind and present different groups of antigens. CD1c is unique in its ability to present e.g. mycobacterial phosphoketides and polyisoprenoids. CD1c is the only CD1 isoform that has been shown to interact both with alpha/beta and gamma/delta T cells. |
| 生物功能 | Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. [UniProt] |
| 研究领域 | Immune System antibody |
| 预测分子量 | 38 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG54264 anti-CD1c antibody [L161] (PE) FACS image
Flow Cytometry: Human peripheral blood cells stained with ARG54264 anti-CD1c antibody [L161] (PE).
