ARG65456
anti-CD205 antibody [HD30]
anti-CD205 antibody [HD30] for Flow cytometry,IHC-Frozen sections,Western blot and Human
Controls and Markers antibody; Immune System antibody
概述
| 产品描述 | Mouse Monoclonal antibody [HD30] recognizes CD205 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, IHC-Fr, WB |
| 特异性 | The clone HD30 recognizes CD205, an approx. 200 kDa C-type lectin transmembrane protein of the MMR (macrophage mannose receptor) family, expressed at high levels on dendritic cells and thymic epithelial cells, and at low levels on lymphocytes, NK cells and monocytes. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | HD30 |
| 同位型 | IgG1 |
| 靶点名称 | CD205 |
| 抗原物种 | Human |
| 抗原 | Recombinant Fc-tagged human CD205 |
| 偶联标记 | Un-conjugated |
| 別名 | Lymphocyte antigen 75; DEC-205; DEC205; Ly-75; CD205; CD antigen CD205 |
应用说明
| 应用建议 |
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | WB: Only non-denatured samples. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from cell culture supernatant by protein-A affinity chromatography. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | LY75 |
| 全名 | lymphocyte antigen 75 |
| 背景介绍 | CD205, also known as DEC-205, is an endocytic receptor of macrophage mannose receptor family. This 205 kDa C-type lectin transmembrane protein mediates adsorptive uptake and its intracellular domain contains coated pit localization sequence and distal acidic motif, which is required for recycling beyond early endosomes through deeper MHC II+ late endosomes and lysosomes. This unique pathway of receptor-mediated uptake proves to be necessary for presentation of antigenic peptides at low doses of ligand. CD205 is responsible for uptake and processing of captured antigens for dendritic cells. |
| 生物功能 | Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes. [UniProt] |
| 研究领域 | Controls and Markers antibody; Immune System antibody |
| 预测分子量 | 198 kDa |
克隆号文献
Generation of anti-human DEC205/CD205 monoclonal antibodies that recognize epitopes conserved in different mammals.
