ARG54254
anti-CD205 antibody [HD30] (PE)
anti-CD205 antibody [HD30] (PE) for Flow cytometry and Human
Controls and Markers antibody; Immune System antibody
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [HD30] recognizes CD205 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The clone HD30 recognizes CD205, an approx. 200 kDa C-type lectin transmembrane protein of the MMR (macrophage mannose receptor) family, expressed at high levels on dendritic cells and thymic epithelial cells, and at low levels on lymphocytes, NK cells and monocytes. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | HD30 |
| 同位型 | IgG1 |
| 靶点名称 | CD205 |
| 抗原物种 | Human |
| 抗原 | Recombinant Fc-tagged human CD205 |
| 偶联标记 | PE |
| 別名 | Lymphocyte antigen 75; DEC-205; DEC205; Ly-75; CD205; CD antigen CD205 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| 缓冲液 | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| 抗菌剂 | 15 mM Sodium azide |
| 稳定剂 | 0.2% (w/v) high-grade protease free BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | LY75 |
| 全名 | lymphocyte antigen 75 |
| 背景介绍 | CD205, also known as DEC-205, is an endocytic receptor of macrophage mannose receptor family. This 205 kDa C-type lectin transmembrane protein mediates adsorptive uptake and its intracellular domain contains coated pit localization sequence and distal acidic motif, which is required for recycling beyond early endosomes through deeper MHC II+ late endosomes and lysosomes. This unique pathway of receptor-mediated uptake proves to be necessary for presentation of antigenic peptides at low doses of ligand. CD205 is responsible for uptake and processing of captured antigens for dendritic cells. |
| 生物功能 | Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes. [UniProt] |
| 研究领域 | Controls and Markers antibody; Immune System antibody |
| 预测分子量 | 198 kDa |
克隆号文献
Generation of anti-human DEC205/CD205 monoclonal antibodies that recognize epitopes conserved in different mammals.
