ARG42334
anti-CD206 / MMR antibody [15-2] (FITC)
anti-CD206 / MMR antibody [15-2] (FITC) for Flow cytometry and Human
概述
| 产品描述 | FITC-conjugated Mouse Monoclonal antibody [15-2] recognizes CD206 / MMR |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody 15-2 (also known as MR15-2) recognizes an extracellular epitope of CD206 (macrophage mannose receptor, MMR), a 162-175 kDa type I transmembrane protein expressed mainly on macrophages, dendritic cells and hepatic or lymphatic endothelial cells, but not on monocytes. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 15-2 |
| 同位型 | IgG1, kappa |
| 靶点名称 | CD206 / MMR |
| 抗原物种 | Human |
| 抗原 | Purified Human MMR. |
| 偶联标记 | FITC |
| 別名 | CLEC13D; C-type lectin domain family 13 member D; Macrophage mannose receptor 1-like protein 1; C-type lectin domain family 13 member D-like; MMR; CLEC13DL; CD206; Macrophage mannose receptor 1; bA541I19.1; CD antigen CD206; MRC1L1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MRC1 |
| 全名 | mannose receptor, C type 1 |
| 背景介绍 | The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. [provided by RefSeq, Sep 2015] |
| 生物功能 | Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens. (Microbial infection) Acts as a receptor for Dengue virus envelope protein E. (Microbial infection) Interacts with Hepatitis B virus envelope protein. [UniProt] |
| 细胞定位 | Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. [UniProt] |
| 产品亮点 | Related products: CD206 antibodies; CD206 ELISA Kits; CD206 Duos / Panels; Anti-Mouse IgG secondary antibodies; Related news: Anti-SerpinB9 therapy, a new strategy for cancer therapy RIP1 activation and pathogenesis of NASH |
| 预测分子量 | 166 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG42334 anti-CD206 / MMR antibody [15-2] (FITC) FACS image
Flow Cytometry: Human stimulated monocytes (GM-CSF + IL-4) stained with ARG42334 anti-CD206 / MMR antibody [15-2] (FITC) at 4 µl / 10^6 cells in 100 µl of cell suspension.
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ARG42334 anti-CD206 / MMR antibody [15-2] (FITC) FACS image
Flow Cytometry: Human stimulated monocytes (GM-CSF + IL-4) stained with ARG42334 anti-CD206 / MMR antibody [15-2] (FITC) at 4 µl / 10^6 cells in 100 µl of cell suspension and ARG53761 anti-CD11c antibody [BU15] (APC) at 10 µl / 10^6 cells in 100 µl of cell suspension.
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ARG42334 anti-CD206 / MMR antibody [15-2] (FITC) FACS image
Flow Cytometry: Separation of Human CD206 positive CD11c positive dendritic cells differentiated upon monocyte stimulation (GM-CSF + IL-4) (red-filled) from non-stimulated lymphocytes (black-dashed). Cells were stained with ARG42334 anti-CD206 / MMR antibody [15-2] (FITC) at 4 µl / 100 µl of peripheral whole blood.
