ARG43453
anti-CD206 / MMR antibody
anti-CD206 / MMR antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Immune System antibody; M1/M2/TAM Marker antibody; Macrophage Marker antibody; M2 Macrophage Marker antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CD206 / MMR |
|---|---|
| 反应物种 | Hu, Ms |
| 预测物种 | Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CD206 / MMR |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to a.a. 21-1140 of Human CD206 / MMR. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Macrophage mannose receptor 1 |
| 別名 | CLEC13D; C-type lectin domain family 13 member D; Macrophage mannose receptor 1-like protein 1; C-type lectin domain family 13 member D-like; MMR; CLEC13DL; CD206; Macrophage mannose receptor 1; bA541I19.1; CD antigen CD206; MRC1L1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | HEK293, RAW264.7 | ||||||
| 实际分子量 | ~185 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MRC1 |
| 全名 | mannose receptor, C type 1 |
| 背景介绍 | The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. CD206 / MMR is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. [provided by RefSeq, Sep 2015] |
| 生物功能 | CD206 / MMR mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens. (Microbial infection) Acts as a receptor for Dengue virus envelope protein E. (Microbial infection) Interacts with Hepatitis B virus envelope protein. [UniProt] |
| 细胞定位 | Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. [UniProt] |
| 产品亮点 | Related products: CD206 antibodies; CD206 ELISA Kits; CD206 Duos / Panels; Anti-Rabbit IgG secondary antibodies; Related news: New antibody panels and duos for Tumor immune microenvironment Tumor-Infiltrating Lymphocytes (TILs) Anti-SerpinB9 therapy, a new strategy for cancer therapy RIP1 activation and pathogenesis of NASH |
| 研究领域 | Immune System antibody; M1/M2/TAM Marker antibody; Macrophage Marker antibody; M2 Macrophage Marker antibody |
| 预测分子量 | 166 kDa |
| 翻译后修饰 | Disulfide bond, Glycoprotein |
检测图片 (3) Click the Picture to Zoom In
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ARG43453 anti-CD206 / MMR antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse spleen tissue. Antigen Retrieval: Heat mediation was performed in EDTA buffer (pH 8.0). The tissue section was blocked with 10% goat serum. The tissue section was then stained with 1 µg/ml of ARG43453 anti-CD206 / MMR antibody, overnight at 4°C.
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ARG43453 anti-CD206 / MMR antibody WB image
Western blot: 50 µg of samples under reducing conditions. HEK293 and Raw264.7 whole cell lysates stained with 0.5 µg/ml of ARG43453 anti-CD206 / MMR antibody, overnight at 4°C.
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ARG43453 anti-CD206 / MMR antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human appendicitis tissue. Antigen Retrieval: Heat mediation was performed in EDTA buffer (pH 8.0). The tissue section was blocked with 10% goat serum. The tissue section was then stained with 1 µg/ml of ARG43453 anti-CD206 / MMR antibody, overnight at 4°C.
