ARG62771
anti-CD21 antibody [LT21]
anti-CD21 antibody [LT21] for Flow cytometry,IHC-Frozen sections and Human,Bovine,Dog,Pig
Immune System antibody
概述
| 产品描述 | Mouse Monoclonal antibody [LT21] recognizes CD21 |
|---|---|
| 反应物种 | Hu, Bov, Dog, Pig |
| 应用 | FACS, IHC-Fr |
| 特异性 | The clone LT21 reacts with CD21 (CR2), a 145 kDa transmembrane glycoprotein (complement C3d receptor - C3dR) expressed on B lymphocytes, follicular dendritic cells, some epithelial cells and a subsets of T lymphocytes. It is not expressed on immature B cells. HLDA VI; WS Code B CD21.1 |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | LT21 |
| 同位型 | IgG1 |
| 靶点名称 | CD21 |
| 抗原物种 | Human |
| 抗原 | IM9 human B-lymphoblastoid cell line |
| 偶联标记 | Un-conjugated |
| 別名 | Cr2; Complement C3d receptor; C3DR; CD21; CD antigen CD21; Complement receptor type 2; SLEB9; CR; CVID7; Epstein-Barr virus receptor; EBV receptor |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from ascites by precipitation methods and ion exchange chromatography. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CR2 |
| 全名 | complement component (3d/Epstein Barr virus) receptor 2 |
| 背景介绍 | CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands. |
| 生物功能 | Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation. [UniProt] |
| 研究领域 | Immune System antibody |
| 预测分子量 | 113 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG62771 anti-CD21 antibody [LT21] FACS image
Flow Cytometry: Human, canine and porcine B lymphocytes stained with ARG62771 anti-CD21 antibody [LT21] and anti-CD79a antibody [HM57].
