ARG20872
anti-CD22 antibody [2D6] (PE-Cyanine 5)
anti-CD22 antibody [2D6] (PE-Cyanine 5) for Cellular activation ,Flow cytometry,ICC/IF,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections and Mouse
Cancer antibody; Developmental Biology antibody; Immune System antibody; Immature B Cell Marker antibody
概述
| 产品描述 | PE-Cyanine 5-conjugated Rat Monoclonal antibody [2D6] recognizes CD22 |
|---|---|
| 反应物种 | Ms |
| 应用 | Cell-Act , FACS, ICC/IF, IHC-Fr, IHC-P |
| 特异性 | Mouse CD22. |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | 2D6 |
| 同位型 | IgG1, kappa |
| 靶点名称 | CD22 |
| 抗原物种 | Mouse |
| 抗原 | Splenic lymphocyte plasma membranes from CBA x C57 F1 mice |
| 偶联标记 | PE-Cyanine 5 |
| 別名 | B-lymphocyte cell adhesion molecule; B-cell receptor CD22; T-cell surface antigen Leu-14; BL-CAM; SIGLEC-2; Sialic acid-binding Ig-like lectin 2; Siglec-2; CD antigen CD22; SIGLEC2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | PBS, 0.1% Sodium azide and Sucrose. |
| 抗菌剂 | 0.1% Sodium azide |
| 稳定剂 | Sucrose |
| 浓度 | 0.1 mg/ml |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | CD22 |
| 全名 | CD22 antigen |
| 生物功能 | Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. [UniProt] |
| 研究领域 | Cancer antibody; Developmental Biology antibody; Immune System antibody; Immature B Cell Marker antibody |
| 预测分子量 | 95 kDa |
| 翻译后修饰 | Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2. Phosphorylated on tyrosine residues by LYN. |
