ARG22550
anti-CD223 / LAG3 antibody [C9B7W]
anti-CD223 / LAG3 antibody [C9B7W] for CyTOF®-candidate,Flow cytometry and Mouse
概述
| 产品描述 | Rat Monoclonal antibody [C9B7W] recognizes CD223 / LAG3 This antibody recognizes murine lymphocyte activation gene-3 (LAG-3), a ~70 kDa activation-induced cell surface molecule that is also referred to as CD223. Murine CD223 is expressed on activated CD4 positive and CD8 positive alpha/beta T lymphocytes and a subset of natural killer (NK) cells. CD223 binds to MHC class II molecules with high affinity and is reported to negatively regulate T cell homeostasis and T cell expansion. Clone C9B7W recognizes an epitope within the D2 domain of CD223. Rat anti Mouse CD223 antibody, clone C9B7W is reported to block the in vitro function of murine LAG-3 but does not block binding of LAG-3 to MHC class II (Workman et al. 2002). |
|---|---|
| 反应物种 | Ms |
| 应用 | CyTOF®-candidate, FACS |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | C9B7W |
| 同位型 | IgG1 |
| 靶点名称 | CD223 / LAG3 |
| 抗原物种 | Mouse |
| 抗原 | Murine CD223 Ig fusion protein. |
| 偶联标记 | Un-conjugated |
| 別名 | CD antigen CD223; CD223; Protein FDC; Lymphocyte activation gene 3 protein; LAG-3 |
应用说明
| 应用建议 |
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| 应用说明 | FACS: Use 10ul of the suggested working dilution to label 10^6 cells in 100ul. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS and 0.09% Sodium azide |
| 抗菌剂 | 0.09% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q61790 Mouse Lymphocyte activation gene 3 protein |
|---|---|
| 基因名称 | Lag3 |
| 全名 | lymphocyte-activation gene 3 |
| 背景介绍 | Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008] |
| 生物功能 | Involved in lymphocyte activation. Binds to HLA class-II antigens. [UniProt] |
| 产品亮点 | Related products: CD223 antibodies; Anti-Rat IgG secondary antibodies; Related news: CyTOF-candidate Antibodies |
| 预测分子量 | 57 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG22550 anti-CD223 / LAG3 antibody [C9B7W] FACS image
Flow Cytometry: CD223 transfected cells stained with ARG22550 anti-CD223 / LAG3 antibody [C9B7W].
