ARG54418
anti-CD253 / TRAIL antibody
anti-CD253 / TRAIL antibody for ICC/IF,Western blot and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CD253 / TRAIL |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, WB |
| 特异性 | This antibody recognizes human TRAIL. |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CD253 / TRAIL |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to aa 261-277 of human TRAIL (accession no. NP_003801). |
| 偶联标记 | Un-conjugated |
| 別名 | TL2; CD253; Protein TRAIL; TNF-related apoptosis-inducing ligand; TRAIL; CD antigen CD253; Apo-2 ligand; Apo-2L; APO2L; Tumor necrosis factor ligand superfamily member 10 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | HeLa and Human brain |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Immunoaffinity chroma-tography |
| 缓冲液 | PBS (pH 7.4) and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P50591 Human Tumor necrosis factor ligand superfamily member 10 |
|---|---|
| 基因名称 | TNFSF10 |
| 全名 | tumor necrosis factor (ligand) superfamily, member 10 |
| 背景介绍 | Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain-containing receptors, TNFR1 and Fas. A novel member of the TNF family has been identified and designated TRAIL (TNF-related apoptosis-inducing ligand) and Apo-2L (Apo-2 ligand). TRAIL is a type II membrane protein and expressed in a variety of human tissues. Two novel death domain-containing receptors, DR4 and DR5, have been identified as the receptor for TRAIL. Like TNF and Fas ligand, TRAIL induces apoptosis and NF- B activation in many tissues and cell types. |
| 生物功能 | Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. [UniProt] |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody |
| 预测分子量 | 33 kDa |
| 翻译后修饰 | Tyrosine phosphorylated by PKDCC/VLK. |
检测图片 (2) Click the Picture to Zoom In
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ARG54418 anti-CD253 / TRAIL antibody WB image
Western blot: 10, 2.5, or 1ng of recombinant extracellular domain of TRAIL stained with ARG54418 anti-CD253 / TRAIL antibody at 1 μg/ml dilution.
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ARG54418 anti-CD253 / TRAIL antibody IHC image
Immunohistochemistry: Human brain stained with ARG54418 anti-CD253 / TRAIL antibody at 20 μg/ml dilution.
