ARG23336
anti-CD253 / TRAIL antibody [B-S23] (PE)
anti-CD253 / TRAIL antibody [B-S23] (PE) for Flow cytometry and Human
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [B-S23] recognizes CD253 / TRAIL |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | This antibody recognizes the TRAIL, APO2L antigen, a 32 kDa protein. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | B-S23 |
| 同位型 | IgG1 |
| 靶点名称 | CD253 / TRAIL |
| 抗原物种 | Human |
| 抗原 | Recombinant human TRAIL |
| 偶联标记 | PE |
| 別名 | TL2; CD253; Protein TRAIL; TNF-related apoptosis-inducing ligand; TRAIL; CD antigen CD253; Apo-2 ligand; Apo-2L; APO2L; Tumor necrosis factor ligand superfamily member 10 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | FACS: Use 10 µl to label 10^6 cells or 100 µl of whole blood. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | PBS, 0.1% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.1% Sodium azide |
| 稳定剂 | 5% BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P50591 Human Tumor necrosis factor ligand superfamily member 10 |
|---|---|
| 基因名称 | TNFSF10 |
| 全名 | tumor necrosis factor (ligand) superfamily, member 10 |
| 背景介绍 | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] |
| 生物功能 | Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. [UniProt] |
| 预测分子量 | 33 kDa |
| 翻译后修饰 | Tyrosine phosphorylated by PKDCC/VLK. [UniProt] |
