ARG54397
anti-CD261 / TRAIL R1 antibody
anti-CD261 / TRAIL R1 antibody for ICC/IF,Western blot and Human
Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes CD261 / TRAIL R1 |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, WB |
| 特异性 | This antibody recognizes full-length human DR4 (57kDa). |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | CD261 / TRAIL R1 |
| 抗原物种 | Human |
| 抗原 | Peptide around aa. 427-445 (C-terminus) of human DR4 protein (accession no. ACC51226). |
| 偶联标记 | Un-conjugated |
| 別名 | TNF-related apoptosis-inducing ligand receptor 1; CD antigen CD261; TRAILR-1; DR4; Tumor necrosis factor receptor superfamily member 10A; CD261; Death receptor 4; APO2; TRAIL receptor 1; TRAIL-R1; TRAILR1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | HeLa and Jurkat |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Immunoaffinity chroma-tography |
| 缓冲液 | PBS (pH 7.4) and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O00220 Human Tumor necrosis factor receptor superfamily member 10A |
|---|---|
| 基因名称 | TNFRSF10A |
| 全名 | tumor necrosis factor receptor superfamily, member 10a |
| 背景介绍 | Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain-containing receptors, TNFR1 and Fas. Another cell death receptor was recently identified and designated DR4. The ligand for DR4 has been designated TRAIL and is a new member of the TNF family. Therefore, DR4 is also called TRAIL receptor-1. DR4 is expressed in most human tissues including spleen, peripheral blood, small intestine, and thymus. Like TNFR1, Fas and DR3, DR4 mediates TRAIL-induced apoptosis and NF-B activation in many tissues and cells. |
| 生物功能 | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Cell Death antibody; Immune System antibody |
| 预测分子量 | 50 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG54397 anti-CD261 / TRAIL R1 antibody WB image
Western blot: HeLa stained with ARG54397 anti-CD261 / TRAIL R1 antibody at 1 μg/ml dilution.
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ARG54397 anti-CD261 / TRAIL R1 antibody ICC/IF image
Immunofluorescence: Jurkat stained with ARG54397 anti-CD261 / TRAIL R1 antibody at 10 μg/ml dilution.
